Developing solutions for tissue regeneration

An unprecedented biomaterial and fabrication platform to achieve a breakthrough in 3D bioprinting technologies and provide innovative scaffolds for damaged or diseased multi-tissue biosystem repair

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InterLynk

strength

Human-based, patient-specific, multimaterial 3D scaffolds

The repair of biological architectures where multiple tissues, as bone, cartilage, ligament and tendon, are arranged together and interact to produce function, is a complex process requiring differential biochemical and mechanical cues. InterLynk partners will develop multimaterial 3D scaffolds with exceptional biofunctionality to induce tissue-specific regeneration of such anatomical structures.

Structural complexity

Multiple materials will be combined in a same scaffold and a portfolio of scaffolds will be developed to mimic the complexity of the microenvironment of multi-tissue biosystems.

Innovative fabrication

New technological solutions for additive manufacturing (AM) will be developed for a fine control of biomaterial spatial organization and distribution during scaffold fabrication.

Bioactivity and biocompatibility

InterLynk scaffolds will be highly bioactive and biocompatible thanks to the combination of different materials with human blood-derived platelet lysates as a common matrix component with cell-recruiting and pro-regenerative capacity.

Customized design

The development of computational modeling tools and the use of medical imaging data will allow to develop personalized medicine approaches to multi-tissue regeneration.

InterLynk

WORK

PLAN

The ambition of the InterLynk Project is to radically transform the design and fabrication of scaffolds for multi-tissue regeneration, and demonstrate the potential of the new regenerative solution in the total replacement of the dissimilar, weight-bearing tissues composing the temporomandibular joint.

Development of a portfolio of biomaterials

In InterLynk, we are crafting a portfolio of highly compatible and biofunctional composite inks and biomaterials, specifically designed for use in additive manufacturing.

Multimaterial additive co-processing

InterLynk will employ advanced virtual modeling tools and innovative technologies in additive manufacturing to produce its cutting-edge scaffolds.

Validation

InterLynk scaffolds will be validated in the temporomandibular joint, a complex and weight-bearing multi-tissue interfacial biosystem. Our scaffolds are designed for full or partial replacement, ensuring robust functionality under demanding physiological conditions.

Strategies for health technology co-creation

We are collaborating closely with key stakeholders, including clinicians, patients, health economists and others in a co-creation process, ensuring that all perspectives are considered. This approach helps us to tailor our solutions to meet the real-world needs and expectations of patients, while also addressing regulatory requirements and market demands.

InterLynk

Consortium

8 partners including universities, a research&technology organization and SMEs, from 4 EU countries

A transdisciplinary team with expertise in materials science, AM systems, manufacturing process modelling, computational biomechanics, tissue engineering, biology and regenerative medicine, will collaborate to expand the frontiers of bioprinting, personalized and regenerative medicine.

METATISSUE Portugal Promoscience Italy UAVR Portugal EnvisionTEC Germany C-UMB Germany Kuros Netherlands INEGI Portugal MU Netherlands InterLynk
UAVR METATISSUE INEGI EnvisionTEC MU C-UMB Kuros Promoscience

GET THE LATEST

Updates on InterLynk achievements and initiatives
EVENT - June 21, 2024
Charité Clinicians Join InterLynk Workshop to Help Shape the Future of Biomaterials
Berlin Hands-on collaboration bridges research and clinical expertise to advance biomaterial innovation.
ABSTRACT SUBMISSIONS - Sep. 15 - Nov. 15, 2025
Call for Abstract Submissions: InterLynk Symposium at TERMIS EU 2025
Freiburg, Germany Submit your innovative research on biofabrication and multi-tissue regeneration to our specialized symposium at the leading TERMIS EU Congress, May 19-23, 2025, in Freiburg, Germany.
PROJECT PUBLICATION - July 6, 2024
Breaking New Ground in Biofabrication: InterLynk Scientists Develop Cutting-Edge Transparent Supporting Bath for Embedding Bioprinting
Researchers from the InterLynk project have pioneered a novel supporting bath for embedding bioprinting enabling the printing of low-viscosity and globular blood-based bioinks. This advancement offers new possibilities for tissue engineering and regeneration.
Discover by playing

Tissue Trek: The InterLynk Scaffold Safari

An educational videogame to learn about regenerative medicine, Interlynk and the EU

Dive into the fascinating world of regenerative medicine with “Tissue Trek: The InterLynk Scaffold Safari”, an educational videogame for kids and adults alike. Embark on an enthralling quest filled with puzzles and challenges. Join Lysa in a race against time to repair a damaged jaw joint and explore the innovative science that powers InterLynk. Ready for an adventure that combines learning with fun? Sign up now and begin your journey!

Project

CONTACTS

João Mano Project coordinator
General enquiries
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