Intranet

The Temporomandibular Joint – a Model of Complexity and Functionality

The temporomandibular joint (TMJ) is one of the most intricate, dynamic, and weight-bearing regions of the human body, comprising multiple tissues such as cartilage, ligaments, tendons, bones, muscles, and a disc.

TMJ - The Ultimate Test for Regenerative Scaffolds

The complex structure and functionality of the TMJ make it an ideal target for validating scaffolds designed for multi-tissue regeneration. By addressing injuries in the TMJ, the project tackles a significant medical challenge while showcasing the scaffolds' potential to repair and restore symmetrical and coordinated movements essential for daily life.

Preclinical Validation

ESTABLISHING PERFORMANCE BENCHMARKS

Before real-world applications, the multimaterial scaffolds undergo extensive preclinical validation to assess their biological and mechanical performance.

  • Material Compatibility

    Testing scaffold integration with surrounding tissues

  • Predictive In-Silico Modeling

    Using advanced simulations to refine scaffold designs

  • Biomechanical Assessments

    Evaluating how scaffolds withstand physiological loads

In Vitro Testing

EVALUATING SCAFFOLDS IN A CONTROLLED ENVIRONMENT

In vitro experiments ensure the scaffolds provide a suitable biological and mechanical environment for cell adhesion and tissue growth.

  • Cell Viability and Proliferation

    Measuring how well human cells interact with the scaffold.

  • Degradation Studies

    Ensuring scaffold breakdown aligns with natural tissue formation.

  • Tissue Growth Simulations

    Observing early-stage regeneration in a lab setting.

In Vivo Validation

ASSESSING REAL-WORLD FUNCTIONALITY

To confirm their effectiveness, the scaffolds are tested in physiologically relevant conditions that mimic human tissue regeneration.

  • Biocompatibility Evaluation

    Assessing inflammatory responses and healing progress.

  • Ethical Standards Compliance

    Ensuring studies adhere to the highest ethical and regulatory standards.

  • Multi-Tissue Regeneration

    Monitoring scaffold performance across cartilage, ligament, and bone interfaces.